Abstract: The recent article by Johnson et al.1 provided for highly stimulating reading. Cannabidiol may attenuate tumor growth in a number of other systemic malignancies. Decreased tumor growth in pulmonary malignancies is seen after administration of cannabidiol. Cannabidiol increases the expression of cyclooxygenase-2 within the cancerous cells.2 Cannabidiol also induces tissue inhibitor of metalloproteinase-1 synthesis and activity. Peroxisome proliferator-activated receptor-gamma expression is augmented at the same time.